New Brunswick’s new CelliGen BLU cell culture bioreactor combines single-use technology with the trusted performance and true scalability of a traditional stirred-tank design. CelliGen BLU has been engineered for high-density animal cell culture in research or production, using interchangeable, single-use, stirred-tank vessels in 5.0 and 14.0 L total volume capacities. A compact controller enables advanced process management for research or cGMP manufacturing.

 Key Benefits include: 

• The single-use vessel eliminates autoclaving and cleaning, provides rapid turnaround between runs, reduces risk of contamination, reduces validation requirements and minimizes initial startup costs.
• Stirred-tank design provides proven performance and scalability.
• The integrated control station enables advanced gas management and process control.
• Unique pH and DO technology makes probe insertion totally noninvasive, eliminating contamination risk and making probe autoclaving unnecessary. 

Single-Use Vessels that Really Perform
The CelliGen BLU disposable bioreactor system is offered with lightweight 5 and 14 liter single-use vessels, pre-sterilized and ready for use right out of the box — no cleaning or sterilization needed. All vessel components in product contact are made of USP Class VI materials and have been tested for leachables and extractables, making them appropriate for GMP environments. Applications include growth of mammalian and animal cell lines in batch, fed-batch and continuous culture.

Advanced System Control
New Brunswick Scientific's powerful RPC (Reactor Process Controller) firmware built provides integrated control up to 32 process parameters,
and includes time-saving recipe features, built-in security and ability to simultaneously monitor up to 8 parameters on user-customizable trend graphs.  Options such as 4-gas mixing and
multiple thermal mass flow controllers provide
all the tools needed to produce high cell densities.  The compact control station also features
integrated pumps and a large, intuitive, color touchscreen interface, with which users of NBS's autoclavable CelliGen 310 and 510 may already be familiar.

• Sophisticated Control Station includes intuitive touchscreen interface with adjustable position, 15" (38 cm) color display; 3 integrated pumps; magnetic-drive motor; control of temperature, pH, DO and 3- or 4-gas mixing; 2 USB ports; and 7 inputs and 7 outputs for addition of ancillary devices.
• Gas Flow Control is via 1, 3 or 4 Thermal Mass Flow Controllers (TMFC) or a Rotameter for sparge line. Rotameter or TMFC for optional gas overlay.
• Additional Options include scale for measuring additions and level, validation packages, gas analyzers, BioCommand® SCADA software and more.

Single-Use Stirred Tank Design

• Interchangeable 5.0 and 14.0 Liter Single-Use, Rigid-Wall Vessels are
  pre-sterilized, ready for use right out of the box -- no cleaning, autoclaving or assembly needed.
• Vessels include pitched-blade impeller, tubing and filters. Vessel headplates incorporate penetrations for RTD temperature sensor, pH and DO probes, addition (3), harvest, overlay, sampling and sparge.

To request a quote or to be among the first to own one of these truly breakthrough bioreactors, click here or contact your local New Brunswick representative.